Publications
-
2023-01-12IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD47-SIRPα interaction and FcɣR engagement by simultaneously binding to CD47 and CD20 of B cellsJifeng Yu 1,3, Song Li2,3, Dianze Chen2, Dandan Liu2, Huiqin Guo2, Chunmei Yang2, Wei Zhang2, Li Zhang2, Gui Zhao2, Xiaoping Tu2,Liang Peng2, Sijin Liu2, Xing Bai2, Yongping Song1, Zhongxing Jiang1, Ruliang Zhang2 and Wenzhi Tian 2✉ Read the li......2023-01-12see more -
2023-01-12SIRPα‑Fc fusion protein IMM01 exhibits dual anti‑tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signalJifeng Yu1†, Song Li2†, Dianze Chen2, Dandan Liu2, Huiqin Guo2, Chunmei Yang2, Wei Zhang2, Li Zhang2,Gui Zhao2, Xiaoping Tu2, Liang Peng2, Sijin Liu2, Xing Bai2, Yongping Song1, Zhongxing Jiang1,Ruliang Zhang2 and Wenzhi Tian2* Read the link: ......2023-01-12see more -
2023-01-12Crystal Structure of Human CD47 in Complex with Engineered SIRPα.D1(N80A)Jifeng Yu , Song Li , Dianze Chen , Dandan Liu , Huiqin Guo , Chunmei Yang , Wei Zhang , Li Zhang ,Gui Zhao , Xiaoping Tu ,Liang Peng , Sijin Liu , Xing Bai , Yongping Song , Zhongxing Jiang ,Ruliang Zhang and Wenzhi Tian Read the link: h......2023-01-12see more -
2022-05-16Advances in the study of CD47-based bispecific antibody in cancer immunotherapyBinglei Zhang, Wei Li , Dandan Fan , Wenzhi Tian , Jian Zhou , Zhenyu Ji, Yongping Song Read the link: https://pubmed.ncbi.nlm.nih.gov/35575882/ Abstract Tumor therapy has entered the era of immunotherapy. Monoclona......2022-05-16see more -
2022-03-29A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung CancerJiayang Liu, Zhefeng Meng, Tongyang Xu, Kudelaidi Kuerban, Songna Wang, Xuyao Zhang, Jiajun Fan, Dianwen Ju, Wenzhi Tian, Xuan Huang, Xiting Huang， Danjie Pan, Huaning Chen, Weili Zhao and Li Ye* Minhang Hospital & Department of Biological Medici......2022-03-29see more